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American Society of Microbiology ABMM Sample Questions:

1. Which of the following organisms is an obligate intracellular bacterium transmitted by arthropod vectors and is a common cause of Rocky Mountain Spotted Fever?

A) Coxiella burnetii
B) Borrelia burgdorferi
C) Chlamydia trachomatis
D) Rickettsia rickettsii

2. A patient develops a febrile illness with a diffuse petechial rash after a camping trip. Serological testing reveals a four-fold rise in antibody titer to Rickettsia rickettsii. The vector responsible for transmitting this organism is a:

A) Mosquito
B) Tick
C) Flea
D) Louse

3. A patient with a history of chronic lung disease develops a severe pneumonia. Bronchoalveolar lavage fluid reveals the presence of numerous cysts containing multiple nuclei, which stain positively with silver stains but poorly with Gram stain. The patient's CD4+ T-cell count is within the normal range. The MOST likely causative organism and the preferred treatment are:

A) Pneumocystis jirovecii; trimethoprim-sulfamethoxazole.
B) Paragonimus westermani; praziquantel.
C) Blastomyces dermatitidis; itraconazole.
D) Histoplasma capsulatum; amphotericin B followed by itraconazole.

4. A patient presents with a chronic, non-healing skin ulcer in a tropical region. Microscopic examination of a biopsy reveals amastigotes within macrophages. Culture of the biopsy on Novy-MacNeal-Nicolle (NNN) medium yields flagellated promastigotes. The MOST likely diagnosis is cutaneous leishmaniasis caused by:

A) Trypanosoma cruzi
B) Leishmania donovani
C) Trypanosoma brucei gambiense
D) Leishmania tropica or Leishmania major

5. A clinical microbiology laboratory is implementing whole-genome sequencing (WGS) for enhanced surveillance of Listeria monocytogenes isolates associated with foodborne outbreaks. WGS provides several advantages over traditional subtyping methods like pulsed-field gel electrophoresis (PFGE). Which of the following is the MOST significant advantage of WGS in this context?

A) Faster turnaround time for obtaining results.
B) Easier standardization and inter-laboratory comparison of data.
C) Lower cost per isolate compared to PFGE.
D) Higher discriminatory power for resolving phylogenetic relationships and identifying outbreakclusters.

Solutions: